Effectiveness of sitagliptin in Cystic Fibrosis with impaired glucose tolerance

Brief Description Of Study

Patients with Cystic Fibrosis often suffer from glucose intolerance. This study will evaluate how effective sitagliptin, a DPP-IV inhibitor, is at improving glycemic control in the Cystic Fibrosis population. Participants will complete baseline testing, then will be asked to take a once-daily pill for 6-months before completing follow-up testing. Participants are compensated $650 for completing study procedures.

Clinical Study Identifier: 818014

Detailed Study Description

This trial will evaluate the participant's metabolic response pre- and post-treatment using a Mixed Meal Tolerance Test and a Glucose Potentiated Arginine Test. After successful Screening, patients will undergo metabolic testing on two separate days before starting study drug or placebo. After 6-months, participants will return for two days of follow-up testing. Participants are compensated $650 for time and inconvenience of Study Visits.

Additional Information About The Study

Please contact the Research Coordinator for with further questions or to schedule a Screening Visit: Jack Eiel jack.eiel@uphs.upenn.edu 215-746-2081



Contact research investigator to learn more about this study by filling out the form below.


To: Research Study Investigator
Subject: I am interested in participating in your Research Study
Dear Investigator,
I'm interested in learning more about and participating in your research study named: Effectiveness of sitagliptin in Cystic Fibrosis with impaired glucose tolerance
Included below is some of my health information:
  1. Condition = Cystic fibrosis
I am hoping to hear back from you and discuss details of the study

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