The purpose of this study is to determine if individuals diagnosed with palmoplantar pustulosis (PPP) would benefit from treatment with Deucravacitinib.   

The research study is being conducted to determine the best dose of an investigational vaccine called BNT163, and to determine if the vaccine is safe and well-tolerated. An investigational vaccine is a vaccine that is not approved by the US Food and Drug Administration (FDA), for use outside of this study. The FDA is the health authority that gives approval for new vaccines for use in the United States.This research study will test different dose levels to determine the dose level that is best tolerated and safe in healthy human participants and then use that dose level to collect more information about the safety and tolerability of BNT163. The vaccine being tested in this study is a vaccine that is being developed for the prevention of genital herpes lesions caused by HSV-2 (herpes simplex 2) and possibly HSV-1 (herpes simplex 1). This study is the first time it will be tested in humans.

The incidence of kidney stone disease, especially among children, has risen rapidly. The goal of this study is to determine how what you eat and drink (your diet), antibiotics you take, and the bacteria that live in your gut (microbiome) contribute to developing kidney stones.

The purpose of this study is to investigate the cause of brain’s reduced control of muscles in the arm after stroke. We will use brain sensors (EEG) and muscle sensors (EMG) to understand the transfer of information from the brain to the muscles in the arm. We will also study the readiness potential which is a signal that indicates that the brain is preparing for a movement before the movement actually begins.