Found 37 cardiovascular-medicine trials
A listing of cardiovascular-medicine medical research trials actively recruiting patient volunteers. Search for closest city to find more detailed information on a research study in your area.
PULSAR
The PULSAR study is a prospective, multicohort, multicenter, non-randomized, single-arm clinical study to evaluate the safety and effectiveness of the Globe Pulsed Field (PF) System for treating patients with symptomatic paroxysmal or persistent atrial fibrillation, compared to performance targets based on relevant, published state-of-the-art literature in the field of catheter-based …
ATRIUM
Phase 3
The primary aim of this trial is to test in a randomized double-blind placebo-controlled study whether abatacept, administered concurrently with corticosteroids, is associated with a reduction in major cardiovascular events among participants with recently diagnosed ICI myocarditis.
BLOCKade of Calcium Channels and Beta Adrenergic Receptors for the Treatment of Hypertension in Heart Failure with Preserved Ejection Fraction
Phase 1
The purpose of the study is to compare how amlodipine versus metoprolol effect blood pressure in people with HFpEF. While hypertension is the most common risk factor for HFpEF, there is little evidence on the potential role of common antihypertensive medications, specifically calcium channel blockers (like amlodipine) and β-blockers …
Medtronic SMall Annuli Randomized To Evolut or Sapien Trial (SMART Trial)
The purpose of this study is to collect information and compare the safety and performance of self-expanding (SE) versus balloon-expandable (BE) transcatheter aortic valve replacement (TAVR) in patients with a small aortic valve.Study participants will be randomized on a 1:1 basis to receive transcatheter aortic valve replacement (TAVR) with either …
PRESTA- Promoting Recovery after Stroke with Amantadine
Phase 2
The research team aims to examine whether amantadine can help patients recover from stroke. This will be a blinded randomized clinical trial. We will randomize patients post-ischemic or hemorrhagic stroke either to the placebo arm or amantadine. Patients will be on study drug or placebo for 1 month but will …
FS-CAMP: Fed-State Cardiac Arteriovenous Metabolomic Profiling
This study will enroll subjects who are coming in for a clinical EP procedure that involves the use of venous, coronary sinus, and arterial line placement. Our patient population is primarily from the surrounding urban and suburban region of Penn Medicine. The research team plans to quantify cardiac metabolism during …
Brain Arterio-Venous Metabolomic Profiling
The research study is being conducted to better understand brain metabolism, i.e. how the brain uses and consumes the various nutrients that are available in the blood. Changes in brain metabolism have been implicated in dementia and psychiatric disorders, as well as short- and long-term outcomes of traumatic brain injury …
DEEPER REVEAL
Compare the safety and efficacy of the Bare Temporary Spur Stent System in subjects with infrapopliteal critical limb ischemia (CLI) to a pre-defined performance goal based on standard percutaneous transluminal balloon angioplasty (PTA). Population: infrapopliteal CLI, Rutherford class 4-5, not considered amenable to conservative medical therapy and require endovascular intervention …
ODYSSEY
Please see section 4 of the full protocol Please see section 4 of the full protocol Please see section 4 of the full protocol
TcMS Approaches for VT
Primary: To determine whether TcMS can reduce the burden of VT in patients with VT storm. Secondary: 1. To determine whether low frequency TcMS or TcMS with TBS is more effective at reducing the burden of VT in patients with VT Storm. 2. To determine the safety of TcMS in …
