Neural and Motor Functional Changes in HIV and Stroke before and after Robot-Assisted Neurorehabilitation

Neural and Motor Functional Changes in HIV and Stroke before and after Robot-Assisted Neurorehabilitation

Brief description of study

Stroke survivors with hemiplegia with and without HIV/AIDS will be evaluated by rehabilitation professionals and asked to perform a battery of assessments including an MRI scan to test the motor and neural changes. They will perform these assessments before and after robot assisted therapy with a simple force-feedback robot that adapts to each individual subject's performance.

Detailed description of study

People living with HIV (PLHIV) are surviving longer thanks to highly active anti-retroviral therapy programs in US and globally in Low and Middle income countries. Unfortunately, the incidence of stroke and other non-communicable diseases are increasing among PLHIV. Stroke is the leading cause of long-term adult disability in worldwide and often leads to motor impairment of the upper and lower extremities resulting in additional disability burden in PLHIV. This pilot study seeks to determine how HIV mediates the effect of stroke on functional activity, the white matter integrity and structural and functional connectivity and its correlation with clinical and motor scores; we will determine if its presence changes the motor outcome after robot-assisted neurorehabilitation. We will test how Theradrive affects neural plasticity after intervention in a cohort of subjects with stroke, as well as stroke survivors wth HIV. This will be done by recruiting approximately 20 human subjects (this includes 8 extra to account for dropout). Exercises will be performed by study subjects and an adaptive controller will monitor patient performance to ensure that exercises are difficult but doable, which is important for maintaining patient motivation.

Eligibility of study

You may be eligible for this study if you meet the following criteria:

  • Conditions:
    AIDS, Hemiplegia, Neurosyphilis, Paresis, HIV infection, Stroke, Chronic HIV-1 infected individuals on HAART
  • Age: Between 19 Years - 100 Years
  • Gender: All
Updated on 25 Jul 2016. Study ID: TX1087

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