Penn Medicine is conducting medical studies to develop new diagnostic and clinical treatments to improve current standards of care.
Recently Added/Updated trials
Integrating Brain, Neurocognitive, and Computational Tools in Opioid Use Disorder (OUD) to Characterize Executive Function and to Predict Clinical Outcomes
Phase 3
The 5-year K01 Mentored Research Scientist proposal will
employ brain, neurocognitive, and computational tools (e.g., machine learning)
to understand the impact of opioid-use disorder (OUD) and common co-occurring
issues on executive function and clinical outcomes.
Opioid and Brain Study
Have problem with opiates? You may qualify for the study if you are: - Between 18–60 years old - In treatment or seeking treatment for opioid use problems - Willing to complete one MRI scan of the brain The study will investigate the psychological and brain mechanisms of opioid use disorder. There will be a screening visit that includes a urine drug test, physical exam, questionnaires and interviews. Eligible participants will undergo a brain MRI session, followed by 6 visits over 25 weeks. The study also includes optional phone/text surveys. MRI uses magnetic fields to take pictures of the brain – it does not use X-rays and is non-invasive. All participants will be compensated for their participation. This study does not provide treatment.
Deucravacitinib for the Treatment of Palmoplantar Pustulosis
The purpose of this study is to determine if individuals diagnosed with palmoplantar pustulosis (PPP) would benefit from treatment with Deucravacitinib.
Healthy Volunteer Study for Herpes Vaccine (BNT163-01)
Phase 1
The research study is being conducted to determine the best dose of an investigational vaccine called BNT163, and to determine if the vaccine is safe and well-tolerated. An investigational vaccine is a vaccine that is not approved by the US Food and Drug Administration (FDA), for use outside of this study. The FDA is the health authority that gives approval for new vaccines for use in the United States.This research study will test different dose levels to determine the dose level that is best tolerated and safe in healthy human participants and then use that dose level to collect more information about the safety and tolerability of BNT163. The vaccine being tested in this study is a vaccine that is being developed for the prevention of genital herpes lesions caused by HSV-2 (herpes simplex 2) and possibly HSV-1 (herpes simplex 1). This study is the first time it will be tested in humans.
Pursuing Optimal Organisms in People with Stones
The incidence of kidney stone disease, especially among children, has risen rapidly. The goal of this study is to determine how what you eat and drink (your diet), antibiotics you take, and the bacteria that live in your gut (microbiome) contribute to developing kidney stones.
CureTalks@Penn interviews Penn Medicine physicians about their cutting edge research and clinical trials. Our goal is to inform patients, care-givers, patient advocates and other physicians about research that occurs at Penn Medicine.
